{"id":21447,"date":"2022-11-21T14:50:50","date_gmt":"2022-11-21T14:50:50","guid":{"rendered":"http:\/\/labgenvet.ca\/?page_id=21447"},"modified":"2026-04-09T19:08:54","modified_gmt":"2026-04-09T19:08:54","slug":"frequencies-of-genetic-disease-mutations-by-cat-breed","status":"publish","type":"page","link":"https:\/\/labgenvet.ca\/en\/frequencies-of-genetic-disease-mutations-by-cat-breed\/","title":{"rendered":"Frequencies of Genetic Disease Mutations by Cat Breed"},"content":{"rendered":"

Frequencies of Genetic Disease Mutations by Cat Breed<\/h3>\n

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Mochi<\/span><\/div><\/div>\n

A knowledge and understanding of mutation frequencies for genetic diseases found within and between cat breeds is a prerequisite for conscientious breeders and veterinarians wishing to make sustainable breeding and informed medical decisions.<\/p>\n

Unfortunately, information on mutation frequency is limited and not always readily accessible within the public domain.\u00a0 This page, “Frequencies of Genetic Disease Mutations by Cat Breed” is an attempt to address this issue.<\/p>\n

Two sets of mutation frequency data for cats are presented, compiled by cat breed and by genetic disease.\u00a0 These data sets are as follows:<\/p>\n

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Eevee<\/span><\/div><\/div>\n

Labgenvet data<\/strong>:\u00a0 In 12 years of operation, the Laboratory of Veterinary Genetics (Labgenvet) was able to perform over 1,000 tests for cat genetic diseases and traits, with samples derived almost exclusively from purebred animals.<\/p>\n

About two thirds of the samples processed were submitted by cat breeders while one third of the samples came from veterinary clinics.<\/p>\n

Samples represented cats mainly (but not exclusively) from Quebec and Eastern Canada.<\/p>\n

Samples were processed for the specific disease mutation requested using techniques of PCR amplification and DNA sequencing.\u00a0 The frequency results presented are inclusive to June 1, 2021.<\/p>\n

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Data from <\/strong>Anderson et al. (2022<\/a>):\u00a0 This published data set represents over 11,000 samples from purebred and domestic cats.\u00a0 Each sample was profiled for\u00a0 50 known mutation varients<\/a> associated with feline genetic diseases.\u00a0 Testing was by hybridization of sample DNA on a custom designed DNA chip microarray.\u00a0 Samples represented predominantly North American and European cats but also cats from other countries.\u00a0 Results are inclusive to 2021.<\/p>\n

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For both data sets<\/strong>, results are presented by cat breed, by disease, by number of samples processed and by percentage of samples recorded as:<\/p>\n

N\/N<\/strong> \u00a0\u00a0\u00a0 homozygous normal (clear) – not at risk of developing the disease.<\/p>\n

M\/N<\/strong> \u00a0\u00a0 heterozygous (carrier) – for recessive mutations, not at risk of developing the disease; for dominant mutations,\u00a0 at risk of developing the disease.<\/p>\n

M\/M<\/strong> \u00a0 homozygous (double) mutant – at risk of developing the disease for both recessive and dominant mutations.<\/p>\n

Abyssinian<\/a><\/p>\n

American Bobtail<\/a><\/p>\n

American Curl<\/a><\/p>\n

American Shorthair<\/a><\/p>\n

Balinese<\/a><\/p>\n

Bengal<\/a><\/p>\n

Birman<\/a><\/p>\n

British Shorthair<\/a><\/p>\n

Burmese<\/a><\/p>\n

Cornish Rex<\/a><\/p>\n

Cymric<\/a><\/p>\n

Devon Rex<\/a><\/p>\n

Donskoy<\/a><\/p>\n

Domestic Cat<\/a><\/p>\n

Egyptian Mau<\/a><\/p>\n

Elf<\/a><\/p>\n

European Shorthair<\/a><\/p>\n

Exotic<\/a><\/p>\n

Havana Brown<\/a><\/p>\n

Highland Lynx<\/a><\/p>\n

Himalayan<\/a><\/p>\n

Kurilian Bobtail<\/a><\/p>\n

LaPerm<\/a><\/p>\n

Lykoi<\/a><\/p>\n

Maine Coon<\/a><\/p>\n

Manx<\/a><\/p>\n

Mekong Bobtail<\/a><\/p>\n

Minuet<\/a><\/p>\n

Munchkin<\/a><\/p>\n

Neva Masqurade<\/a><\/p>\n

Norwegian Forest Cat<\/a><\/p>\n

Ocicat<\/a><\/p>\n

Oriental Longhair<\/a><\/p>\n

Oriental Shorthair<\/a><\/p>\n

Persian<\/a><\/p>\n

Peterbald<\/a><\/p>\n

Pixiebob<\/a><\/p>\n

Ragamuffin<\/a><\/p>\n

Ragdoll<\/a><\/p>\n

Russian Blue<\/a><\/p>\n

Savannah<\/a><\/p>\n

Scottish Fold<\/a><\/p>\n

Selkirk Rex<\/a><\/p>\n

Siamese<\/a><\/p>\n

Siberian<\/a><\/p>\n

Singapura<\/a><\/p>\n

Somali<\/a><\/p>\n

Sphynx<\/a><\/p>\n

Tennessee Rex<\/a><\/p>\n

Thai Cat<\/a><\/p>\n

Tonkinese<\/a><\/p>\n

Toybob<\/a><\/p>\n

Toyger<\/a><\/p>\n

Turkish Angora<\/a><\/p>\n

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Frequencies of Genetic Disease Mutations by Cat Breed [vc_row][\/vc_row] [vc_row] A knowledge and understanding of mutation frequencies for genetic diseases found within and between cat breeds is a prerequisite for conscientious breeders and veterinarians wishing to make sustainable breeding and informed medical decisions. Unfortunately, information on mutation frequency is limited and not always readily accessible…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-21447","page","type-page","status-publish","hentry","description-off"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/pages\/21447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/comments?post=21447"}],"version-history":[{"count":65,"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/pages\/21447\/revisions"}],"predecessor-version":[{"id":24540,"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/pages\/21447\/revisions\/24540"}],"wp:attachment":[{"href":"https:\/\/labgenvet.ca\/en\/wp-json\/wp\/v2\/media?parent=21447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}